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Available PET Radiotracers

Approved for Clinical Use

Fluorine-18

  • FDG - glucose metabolism

  • FEPPA - TSPO/inflammation

  • florbetapir - amyloid plaque

  • flortaucipir - neurofibillary tangles

  • NaF - bone density

  • PSMA-1007 - prostate cancer

 

Short-lived isotopes

  • N-13 Ammonia - blood flow

  • O-15 water - blood flow

  • O-15 oxygen (direct to scanner)

 

Solid Target Products

  • Tc-99m pertechnetate

  • > 200 GBq Ga-68 

  • Zr-89 (oxalate and chloride)

​Preclinical or In Validation

All clinical tracers

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Fluorine-18

  • FEOBV - acetylcholine storage

  • SynVesT-1 - synaptic density

  • BF4 - Na/I symporter

  • Flurpiridaz - mitochondrial complex 1

  • FAPI-74 - fibroblast activation protein

  • F-AraG - Activated T-cells

  • L-FDG - perfusion/altered metabolism

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Carbon-11

  • HED - sympathetic innervation

  • DTBZ - presynaptic monoamine storage

  • Raclopride - dopamine receptor antagonist

  • PHNO - dopamine receptor agonist

  • UCB-J - synaptic density

  • butanol - brain permeability 

If materials are commercially available, new preclinical radiotracers are easy to add.

Check out ABX and Pharmasynth for examples.

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